Endocrine Abstracts

Genetic counseling has long been an integral component of the care of individuals and families with hereditary endocrine neoplasia syndromes. Molecular biology has made a great progress during the past years, and genetic testing and genetic counseling have received more and more public attention. The recent progress, especially in the next-generation sequencing (NGS) technology allows multiple genes or even the whole-genome to be sequenced with high resolution and speed. Nowad...

Introduction: In sporadic acromegaly, downregulation of AIP protein of the adenomas associates with invasive tumour features and reduced response to somatostatin analogue treatment. AIP is a regulator of Gαi signaling, but it is not known how the biological function of the Gαi pathway is controlled.Aim: To study somatic GNAS and AIP mutation status, AIP and Gαi-2 protein expressions, Ki67 proliferation indices, and clinical parameters in p...